兔抗FAM110B多克隆抗体

Background:

FAM110B (Familiarity with sequence similarity 110, member B) is a 370 amino acid protein, which contains several motifs that are conserved among FAM110 family members and a proline-rich region through which it probably binds proteins. Localized to the nucleus where they associate with centrosomes, FAM110A, FAM110B and FAM110C accumulate at the spindle poles during mitosis. Expression of FAM110B and FAM110C impairs cell cycle progression through G1 phase. FAM110B is expressed in testis, thyroid and spleen and is found at lower levels in ovary, adrenal gland, stomach, trachea, intestine, lymph node, spinal cord and prostate. The gene encoding FAM110B maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. May be involved in tumor progression.

Applications:

ELISA, IHC

Name of antibody:

FAM110B

Immunogen:

Fusion protein of human FAM110B

Full name:

family with sequence similarity 110 member B

Synonyms:

C8orf72

SwissProt:

Q8TC76

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

40-200