兔抗CNTNAP1多克隆抗体

Background:

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Applications:

ELISA, WB, IHC

Name of antibody:

CNTNAP1

Immunogen:

Synthetic peptide of human CNTNAP1

Full name:

contactin associated protein 1

Synonyms:

P190; CASPR; NRXN4; CNTNAP

SwissProt:

P78357

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human liver cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

156 kDa

WB Positive control:

A172 cell lysate

WB Recommended dilution:

200-1000