兔抗CGAS多克隆抗体

Background:

cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Applications:

ELISA, WB, IHC

Name of antibody:

CGAS

Immunogen:

Synthetic peptide of human CGAS

Full name:

cyclic GMP-AMP synthase

Synonyms:

MB21D1; h-cGAS; C6orf150

SwissProt:

Q8N884

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

59 kDa

WB Positive control:

HT-29 and Lovo cell lysates

WB Recommended dilution:

500-2000