小鼠抗SHMT2单克隆抗体

Background:

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

Applications:

WB, IHC

Name of antibody:

SHMT2

Immunogen:

Fusion protein of human SHMT2

Full name:

serine hydroxymethyltransferase 2

Synonyms:

GLYA; SHMT; HEL-S-51e

SwissProt:

P34897

IHC positive control:

Human endometrial cancer and Human breast tissue; Human colorectal cancer and Human breast cancer

IHC Recommend dilution:

200-500

WB Predicted band size:

56 KD

WB Positive control:

Hela, 293T, HepG2, MCF7, Jurkat, K562 and A549 cell lysates

WB Recommended dilution:

500-2000