兔抗KDM7A多克隆抗体

Background:

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.

Applications:

ELISA, IHC

Name of antibody:

KDM7A

Immunogen:

Synthetic peptide of human KDM7A

Full name:

lysine demethylase 7A

Synonyms:

JHDM1D

SwissProt:

Q6ZMT4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human ovarian cancer

IHC Recommend dilution:

30-150