兔抗AGBL2多克隆抗体

Background:

Metallocarboxypeptidase that may play a role in the processing of tubulin. Knockdown of AGBL2 results in a failure of the cell to detyrosinate the C-terminal EEY region of α-tubulin and indicates that, it is a candidate for the long sought after tubulin tyrosine carboxypeptidase important in regulation of microtubule dynamics. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and identify a novel area for therapeutic intervention.

Applications:

ELISA, IHC

Name of antibody:

AGBL2

Immunogen:

Fusion protein of human AGBL2

Full name:

ATP/GTP binding protein-like 2

SwissProt:

Q5U5Z8

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

25-100