小鼠抗ATG4B单克隆抗体

Background:

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Applications:

WB, IHC

Name of antibody:

ATG4B

Immunogen:

Fusion protein of human ATG4B

Full name:

autophagy related 4B cysteine peptidase

Synonyms:

APG4B; AUTL1

SwissProt:

Q9Y4P1

IHC positive control:

Human endometrial cancer

IHC Recommend dilution:

500-2000

WB Predicted band size:

44 KD

WB Positive control:

Ramos, 293T, Jurkat, Hela, COLO205, U251, PC3 cell lysates

WB Recommended dilution:

500-2000