兔抗NR2F6多克隆抗体

Background:

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Applications:

WB, IHC, IF

Name of antibody:

NR2F6

Immunogen:

Synthesized peptide derived from N-terminal of human NR2F6.

Full name:

nuclear receptor subfamily 2, group F, member 6

Synonyms：

EAR2; EAR-2; ERBAL2

SwissProt:

P10588

IHC positive control:

Human cervix carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

43 kDa

WB Positive control:

Hela cells, 293 cells and Huvec cells lysates

WB Recommended dilution:

500-3000

IF positive control:

HepG2 cells

IF Recommend dilution:

100-500