兔抗KLHL3多克隆抗体

Background:

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [

Applications:

WB, IHC, IF

Name of antibody:

KLHL3

Immunogen:

Synthesized peptide derived from N-terminal of human KLHL3.

Full name:

kelch-like family member 3

Synonyms：

PHA2D

SwissProt:

Q9UH77/Q8N4I8

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

65 kDa

WB Positive control:

RAW264.7 cells and NIH/3T3 cells lysates

WB Recommended dilution:

500-3000

IF positive control:

A549 cells

IF Recommend dilution:

100-500