兔抗HYAL3多克隆抗体

Background:

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.

Applications:

ELISA, WB, IHC

Name of antibody:

HYAL3

Immunogen:

Fusion protein of human HYAL3

Full name:

hyaluronoglucosaminidase 3

Synonyms：

LUCA3; HYAL-3; LUCA-3

SwissProt:

O43820

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and human colon cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

47 kDa

WB Positive control:

Human kidney tissue, HepG2 cells and human testis tissue

WB Recommended dilution:

500-2000