兔抗SF3B3多克隆抗体

Background:

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Applications:

ELISA, IHC

Name of antibody:

SF3B3

Immunogen:

Fusion protein of human SF3B3

Full name:

splicing factor 3b subunit 3

Synonyms:

RSE1; SAP130; SF3b130; STAF130

SwissProt:

Q15393

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human thyroid cancer

IHC Recommend dilution:

50-300