小鼠抗NKX2-1单克隆抗体

Background:

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Applications:

WB, IHC

Name of antibody:

NKX2-1

Immunogen:

Fusion protein of human NKX2-1

Full name:

NK2 homeobox 1

Synonyms:

BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1

SwissProt:

P43699

IHC positive control:

Human lung cancer and Human thyroid tissue; Human lung tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

39 KD

WB Positive control:

H1975, A549, H1650, H228 cell lysates

WB Recommended dilution:

200-1000