兔抗CDH12多克隆抗体

Background:

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Applications:

ELISA, IHC

Name of antibody:

CDH12

Immunogen:

Synthetic peptide of human CDH12

Full name:

cadherin 12

Synonyms:

CDHB

SwissProt:

P55289

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human liver cancer

IHC Recommend dilution:

25-50