小鼠抗CYP17A1单克隆抗体

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.

Applications:

WB

Name of antibody:

CYP17A1

Immunogen:

Fusion protein of human CYP17A1

Full name:

cytochrome P450 family 17 subfamily A member 1

Synonyms:

CPT7; CYP17; S17AH; P450C17

SwissProt:

P05093

WB Predicted band size:

57 kDa

WB Positive control:

A549, HepG2 and Hela cell lysates

WB Recommended dilution:

1000-5000