小鼠抗FOLH1单克隆抗体

Background:

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq].

Applications:

WB, IHC, IF, FC

Name of antibody:

FOLH1

Immunogen:

Fusion protein of human FOLH1

Full name:

folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), transcript variant 1

Synonyms:

FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA

SwissProt:

Q04609

IHC positive control:

adenocarcinoma of human endometrium tissue and carcinoma of human prostate tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

84 kDa

WB Positive control:

Hela, SVT2, COS7, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000