兔抗ARHGEF3多克隆抗体

Background:

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

ARHGEF3

Immunogen:

Fusion protein of human ARHGEF3

Full name:

Rho guanine nucleotide exchange factor (GEF) 3

Synonyms：

GEF3; STA3; XPLN

SwissProt:

Q9NR81

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human colon cancer

IHC Recommend dilution:

25-100