小鼠抗CYP7B1单克隆抗体

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder.

Applications:

WB, IHC

Name of antibody:

CYP7B1

Immunogen:

Fusion protein of human CYP7B1

Full name:

cytochrome P450 family 7 subfamily B member 1

Synonyms:

CP7B; CBAS3; SPG5A

SwissProt:

O75881

IHC positive control:

Human breast tissue and Human breast cancer; Human liver tissue and Human endometrial cancer

IHC Recommend dilution:

200-500

WB Predicted band size:

58 KD

WB Positive control:

Hela and PC3 cell, Human brain tissue lysates

WB Recommended dilution:

200-1000