兔抗CBFA2T2多克隆抗体

Background:

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Applications:

ELISA, WB

Name of antibody:

CBFA2T2

Immunogen:

Fusion protein of human CBFA2T2

Full name:

CBFA2/RUNX1 translocation partner 2

Synonyms:

EHT; p85; MTGR1; ZMYND3

SwissProt:

O43439

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

67 kDa

WB Positive control:

293T, Raji, Jurkat, HepG2 cell lysates

WB Recommended dilution:

1000-5000