小鼠抗CHD3(C-term)单克隆抗体

Background:

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Applications:

WB, IF, IP

Name of antibody:

CHD3(C-term)

Immunogen:

Fusion protein of human CHD3

Full name:

chromodomain helicase DNA binding protein 3

Synonyms:

ZFH; Mi-2a; Mi2-ALPHA

SwissProt:

Q12873

WB Predicted band size:

227 kDa

WB Positive control:

NTERA2, 3T3, C6, K562 and Hela cell lysates

WB Recommended dilution:

1000-5000

IF positive control:

Hela cells

IF Recommend dilution:

200-400