小鼠抗HNRNPK单克隆抗体

Background:

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.

Applications:

ELISA, WB

Name of antibody:

HNRNPK

Immunogen:

Fusion protein of human HNRNPK

Full name:

heterogeneous nuclear ribonucleoprotein K

Synonyms:

AUKS; CSBP; TUNP; HNRPK

SwissProt:

P61978

WB Predicted band size:

51 kDa

WB Positive control:

HeLa whole cell lysate

WB Recommended dilution:

500-2000