兔抗ABCC2多克隆抗体

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Applications:

ELISA, IHC

Name of antibody:

ABCC2

Immunogen:

Synthetic peptide of humanABCC2

Full name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms：

DJS; MRP2; cMRP; ABC30; CMOAT

SwissProt:

Q92887

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150