小鼠抗CD1C单克隆抗体

Background:

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul

Applications:

WB, IHC, IF

Name of antibody:

CD1C

Immunogen:

Fusion protein of human CD1C

Full name:

CD1c molecule (CD1C)

Synonyms:

BDCA1; CD1; CD1A; R7

SwissProt:

P29017

IHC positive control:

carcinoma of human lung tissue and human endometrium tissue; human lymph node tissue and human tonsil tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

38 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000