兔抗ERI1多克隆抗体

Background:

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Applications:

WB

Name of antibody:

ERI1

Immunogen:

Synthesized peptide derived from internal of human ERI1.

Full name:

exoribonuclease 1

Synonyms：

HEXO; THEX1; 3'HEXO

SwissProt:

Q8IV48

WB Predicted band size:

40 kDa

WB Positive control:

COLO205 cells lysate

WB Recommended dilution:

500-3000