小鼠抗CCT8L2单克隆抗体

Background:

CESK1, also known as CCT8L2 (chaperonin containing TCP1, subunit 8 theta-like 2), is a 557 amino acid protein that localizes to the cytoplasm and is thought to function as a molecular chaperone, possibly assisting protein folding after ATP hydrolysis. CESK1 belongs to the TCP-1 chaperonin family and is encoded by a gene which maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein Bcr-Abl, a potent cell proliferation activator found in several types of leukemias.

Applications:

WB, IHC, IF

Name of antibody:

CCT8L2

Immunogen:

Fusion protein of human CCT8L2

Full name:

chaperonin containing TCP1, subunit 8 (theta)-like 2 (CCT8L2)

Synonyms:

CESK1

SwissProt:

Q96SF2

IHC positive control:

human colon tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

59 kDa

WB Positive control:

A549, MCF-7 cell lysates

WB Recommended dilution:

200-1000