小鼠抗CD3E单克隆抗体

Background:

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC, IF

Name of antibody:

CD3E

Immunogen:

Fusion protein of human CD3E

Full name:

CD3e molecule, epsilon (CD3-TCR complex) (CD3E)

Synonyms:

IMD18; T3E; TCRE

SwissProt:

P07766

IHC positive control:

human liver tissue and human lymphoma tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

23 kDa

WB Positive control:

COS7, Jurkat, MDCK cell lysates

WB Recommended dilution:

200-1000