小鼠抗FHIT单克隆抗体

Background:

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.

Applications:

WB, IHC

Name of antibody:

FHIT

Immunogen:

Fusion protein of human FHIT

Full name:

fragile histidine triad

Synonyms:

FRA3B; AP3Aase

SwissProt:

P49789

IHC positive control:

Human kidney tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

17 KD

WB Positive control:

Rat brain tissue, Rat kidney tissue lysates

WB Recommended dilution:

200-1000