兔抗KITLG多克隆抗体

Background:

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Applications:

WB

Name of antibody:

KITLG

Immunogen:

Synthetic peptide of human KITLG

Full name:

KIT ligand

Synonyms：

SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7

SwissProt:

P21583

WB Predicted band size:

31 kDa

WB Positive control:

A549, A431, Hela and 3T3 cells

WB Recommended dilution:

500-1000