小鼠抗ALDH7A1单克隆抗体

Background:

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.

Applications:

WB, IHC

Name of antibody:

ALDH7A1

Immunogen:

Fusion protein of human ALDH7A1

Full name:

aldehyde dehydrogenase 7 family member A1

Synonyms:

EPD; PDE; ATQ1

SwissProt:

P49419

IHC positive control:

Human endometrial cancer and Human lung cancer; Human appendix tissue

IHC Recommend dilution:

500-2000

WB Predicted band size:

58 KD

WB Positive control:

HepG2 cell, Mouse liver tissue lysates

WB Recommended dilution:

500-2000