小鼠抗GPR151单克隆抗体

Background:

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Applications:

WB

Name of antibody:

GPR151

Immunogen:

Fusion protein of human GPR151

Full name:

G protein-coupled receptor 151

Synonyms:

GPCR; PGR7; GALR4; GALRL; GPCR-2037

SwissProt:

Q8TDV0

WB Predicted band size:

47 KD

WB Positive control:

HUVEC cell lysate

WB Recommended dilution:

500-2000