小鼠抗AGR2单克隆抗体

Background:

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.

Applications:

WB, IHC

Name of antibody:

AGR2

Immunogen:

Fusion protein of human AGR2

Full name:

anterior gradient 2, protein disulphide isomerase family member

Synonyms:

AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

SwissProt:

O95994

IHC positive control:

Human prostate tissue and Human breast cancer

IHC Recommend dilution:

500-2000

WB Predicted band size:

20 KD

WB Positive control:

AGR2, AGR3 cell lysates

WB Recommended dilution:

500-2000