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Background: |
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. |
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Applications: |
WB |
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Name of antibody: |
TGFBR2 |
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Immunogen: |
Synthesized peptide derived from human TGF β Receptor II antibody. |
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Full name: |
transforming growth factor, beta receptor II (70/80kDa) |
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Synonyms： |
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII |
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SwissProt: |
P37173 |
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WB Predicted band size: |
65 kDa |
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WB Positive control: |
HepG2 cells lysate |
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WB Recommended dilution: |
500-3000 |
