兔抗CHRNA2多克隆抗体

Background:

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Applications:

ELISA, WB, IHC

Name of antibody:

CHRNA2

Immunogen:

Synthetic peptide of human CHRNA2

Full name:

cholinergic receptor, nicotinic, alpha 2 (neuronal)

SwissProt:

Q15822

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and Human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

60 kDa

WB Positive control:

A172 and A549 cells

WB Recommended dilution:

500-2000