兔抗Synpr多克隆抗体

Background:

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).

Applications:

WB

Name of antibody:

Synpr

Immunogen:

Synthetic peptide of Rat Synpr

Full name:

Synpr

Synonyms：

synaptoporin

SwissProt:

P22831

WB Predicted band size:

29 kDa

WB Positive control:

Rat brain and mouse brain

WB Recommended dilution:

500-1000