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021-54845833/15800441009
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Background: |
Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). |
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Applications: |
WB |
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Name of antibody: |
Synpr |
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Immunogen: |
Synthetic peptide of Rat Synpr |
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Full name: |
Synpr |
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Synonyms： |
synaptoporin |
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SwissProt: |
P22831 |
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WB Predicted band size: |
29 kDa |
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WB Positive control: |
Rat brain and mouse brain |
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WB Recommended dilution: |
500-1000 |
