兔抗NR1H2多克隆抗体

Background:

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

Applications:

ELISA, IHC

Name of antibody:

NR1H2

Immunogen:

Fusion protein of human NR1H2

Full name:

nuclear receptor subfamily 1 group H member 2

Synonyms:

NER; UNR; LXRB; LXR-b; NER-I; RIP15

SwissProt:

P55055

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

150-300