小鼠抗TBL1XR1单克隆抗体

Background:

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.

Applications:

WB, IHC, IF

Name of antibody:

TBL1XR1

Immunogen:

Fusion protein of human TBL1XR1

Full name:

transducin beta like 1 X-linked receptor 1

Synonyms:

C21; DC42; IRA1; MRD41; TBLR1

SwissProt:

Q9BZK7

IHC positive control:

Human breast cancer

IHC Recommend dilution:

500-1000

WB Predicted band size:

56 kDa

WB Positive control:

Mouse brain tissue, Mouse heart tissue and K562 cell lysates

WB Recommended dilution:

1000-5000

IF positive control:

Hela cells

IF Recommend dilution:

100-200