兔抗APLF(Ab-116)多克隆抗体

Background:

Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.

Applications:

WB, IHC

Name of antibody:

APLF(Ab-116)

Immunogen:

Synthesized non-phosphopeptide derived from human APLF around the phosphorylation site of serine 116 (R-N-S(p)-Q-V).

Full name:

aprataxin and PNKP like factor

Synonyms：

APFL; PALF; Xip1; ZCCHH1; C2orf13

SwissProt:

Q8IW19

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

60 kDa

WB Positive control:

HT-29 cells lysate

WB Recommended dilution:

500-3000