兔抗FBXO32多克隆抗体

Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, IHC

Name of antibody:

FBXO32

Immunogen:

Synthetic peptide corresponding to a region derived from 69-82 amino acids of human FBXO32

Full name:

F-box protein 32

Synonyms:

Fbx32; MAFbx

SwissProt:

Q969P5

ELISA Recommended dilution:

5000-10000

IHC Positive control:

Human liver cancer;Human prostate cancer

IHC Recommended dilution:

30-150