兔抗DUSP1多克隆抗体

Background:

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Applications:

ELISA, WB, IHC

Name of antibody:

DUSP1

Immunogen:

Synthetic peptide of humanDUSP1

Full name:

dual specificity phosphatase 1

Synonyms：

HVH1, MKP1, CL100, MKP-1, PTPN10

SwissProt:

P28562

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

39 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

200-1000