兔抗APC多克隆抗体

Background:

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Applications:

ELISA, IHC

Name of antibody:

APC

Immunogen:

Synthetic peptide of human APC

Full name:

WNT signaling pathway regulator

Synonyms:

GS; DP2; DP3; BTPS2; DP2.5; PPP1R46

SwissProt:

P25054

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human thyroid cancer

IHC Recommend dilution:

40-200