小鼠抗PPP1CA单克隆抗体

Background:

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC

Name of antibody:

PPP1CA

Immunogen:

Fusion protein of human PPP1CA

Full name:

protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 3

Synonyms:

PP-1A; PP1A; PP1alpha; PPP1A

SwissProt:

P62136

IHC positive control:

human colon tissue and adenocarcinoma of human colon tissue; human liver tissue and human pancreas tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

38 kDa

WB Positive control:

Hela, SVT2, A549, COS7, Jurkat, PC-12 and MCF7 cell lysates

WB Recommended dilution:

200-1000