小鼠抗PKM2单克隆抗体

Background:

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.

Applications:

WB, IHC

Name of antibody:

PKM2

Immunogen:

Synthetic peptide of human PKM2

Full name:

pyruvate kinase, muscle, M2 isoform

Synonyms:

PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30

SwissProt:

P14618

IHC positive control:

human colon tissue and carcinoma of human kidney tissue; human liver tissue and carcinoma of human liver tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

58 kDa

WB Positive control:

SVT2, MDCK, PC12 cell lysates

WB Recommended dilution:

500-2000