兔抗CEP104多克隆抗体

Background:

This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains, two glycosylation sites, four cysteine-rich motifs, and two regions with homology to the glutamate receptor ionotropic, NMDA 1 protein. During ciliogenesis, the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium. Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips. Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome, which is characterized by a distinctive mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental delay, and ataxia.

Applications:

ELISA, IHC

Name of antibody:

CEP104

Immunogen:

Synthetic peptide of human CEP104

Full name:

centrosomal protein 104

Synonyms:

GlyBP; ROC22; JBTS25; CFAP256; KIAA0562

SwissProt:

O60308

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human liver cancer

IHC Recommend dilution:

25-100