小鼠抗PNP单克隆抗体

Background:

This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Applications:

ELISA, WB

Name of antibody:

PNP

Immunogen:

Fusion protein of human PNP

Full name:

purine nucleoside phosphorylase

Synonyms:

NP; PUNP; PRO1837

SwissProt:

P00491

WB Predicted band size:

32 kDa

WB Positive control:

HEK293 whole cell lysate

WB Recommended dilution:

1000-5000