兔抗PTAFR多克隆抗体

Background:

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

PTAFR

Immunogen:

Synthetic peptide of human PTAFR

Full name:

Platelet-activating factor receptor

Synonyms:

PAFR

SwissProt:

P25105

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

25-100