小鼠抗GRK2单克隆抗体

Background:

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Applications:

WB

Name of antibody:

GRK2

Immunogen:

Fusion protein of human GRK2

Full name:

G protein-coupled receptor kinase 2

Synonyms:

BARK1; ADRBK1; BETA-ARK1

SwissProt:

P25098

WB Predicted band size:

80 kDa

WB Positive control:

THP-1 and Ramos cell lysates

WB Recommended dilution:

200-1000