小鼠抗Pan-CDH单克隆抗体

Background:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Applications:

IHC

Name of antibody:

Pan-CDH

Immunogen:

Synthetic peptide of human Pan-CDH

Full name:

pan-cadherin

IHC positive control:

human colon tissue and adenocarcinoma of human colon tissue andhuman prostate tissue and carcinoma of human prostate tissue

IHC Recommend dilution:

30-150