小鼠抗FADD单克隆抗体

Background:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Applications:

WB, IP

Name of antibody:

FADD

Immunogen:

Fusion protein of human FADD

Full name:

Fas associated via death domain

Synonyms:

GIG3; MORT1

SwissProt:

Q13158

WB Predicted band size:

23 kDa

WB Positive control:

SW480, Jurkat and Hela cell lysates

WB Recommended dilution:

500-2000