小鼠抗TIMM8A单克隆抗体

Background:

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:

WB, IHC

Name of antibody:

TIMM8A

Immunogen:

Fusion protein of human TIMM8A

Full name:

translocase of inner mitochondrial membrane 8A

Synonyms:

DDP; MTS; DDP1; DFN1; TIM8

SwissProt:

O60220

IHC positive control:

Human prostate cancer and Human endometrial cancer; Human liver tissue and Human colorectal cancer

IHC Recommend dilution:

200-500

WB Predicted band size:

11 KD

WB Positive control:

293T, HepG2 cell lysates

WB Recommended dilution:

200-1000