兔抗AXIN2多克隆抗体

Background:

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Applications:

ELISA, WB, IHC

Name of antibody:

AXIN2

Immunogen:

Fusion protein of human AXIN2

Full name:

axin 2

Synonyms：

AXIL; ODCRCS

SwissProt:

Q9Y2T1

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer and human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

94 kDa

WB Positive control:

Human ileum adenocarcinoma tissue

WB Recommended dilution:

200-1000