兔抗CR1多克隆抗体

Background:

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.

Applications:

ELISA, IHC

Name of antibody:

CR1

Immunogen:

Synthetic peptide of human CR1

Full name:

complement component (3b/4b) receptor 1 (Knops blood group)

Synonyms：

KN; C3BR; C4BR; CD35

SwissProt:

P17927

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

25-100